Hi, I've been taking Cymbalta for over two years for depression. I take 60 mgs and never had that reaction in fact it makes me really tired if I take it early in the day, so I have to take it in the evening. (I wish it would pep me up a little, I could certainly use it!) Maybe ask your doctor for a mood stabilizer to go along with it, or something like Klonopin for the anxiety/agitation. I take that for anxiety as needed and it really helps. Good luck!