Who's going with you? Will you be driving or riding?
When I use to have take road trips w/my ex-husband and he was driving I would sometimes get in the back seat w/a pillow and blanket and try to sleep. When I was up front I would put in a book-on-tape and close my eyes and listen to the story. I always made sure I was comfortable. I'd take off my shoes, have my pillow (even up front) to lean on and I've have snacks, drinks and magazines with me. It really helped to make myself feel relaxed and the car actually became my "safe-place."
Best of luck and keep us posted. If you feel anxious during the week, come in here and vent. We're here for you.